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cGAS-STING signaling pathway is also capable of acting on the ER

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SIRT3 overexpression in HSCs improves the function of distant tissues through myeloid cells Adoptive transfer experiments demonstrated that splenocytes from aged mice were sufficient to induce systemic senescence in young recipients, despite the short-lived nature of donor immune cells, supporting the concept that relatively small numbers of functionally altered immune cells can exert broad physiological effects through systemic signaling mechanisms, without requiring long-term engraftment 52

In both instances, we observed an increase in senescence on cisplatin treatment and a reduction in the cisplatin + RSL3 sections (Fig

Ingram DK, Young J, Mattison JA: Calorie restriction in nonhuman primates: assessing effects on brain and behavioral aging