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Unlike prior reviews that focus on single disease contexts or limited pathways, 7,459 this work integrates autophagy regulation across diverse physiological and pathological conditions, including cancer, neurodegenerative diseases, cardiovascular and metabolic syndromes, muscular atrophy, and aging-related degeneration

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IL-4, therefore, when overexpressed by viral engineering, or insufficient GSH concentrations that skew T helper response patterns to Th2, can result in lethal accumulations of hydroperoxyls by up-regulating 12-and 15- lipoxygenases to produce increased quantities of 12- and 15- HPETE's

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