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Separate mechanism from benefit

In this review, we discuss how the neonatal Fc receptor (FcRn) acts as a regulator of the high levels of not only IgG Abs, but also albumin, by rescuing both these soluble proteins from cellular catabolism, and how a molecular and cellular understanding of this complex biology has spurred an intense interest in the development of FcRn-targeting strategies for the treatment of IgG-driven autoimmune diseases

These include: Vegetarians and vegans- Because b12 is found in meat, fish and dairy products, people following a plant based diet may struggle to eat enough food containing b12, leaving them susceptible to developing a deficiency

10.1016/j.stemcr.2015.04.001 43 Si-TayebK.NotoF