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Steven Galetta, chairman of neurology at NYU Langone Medical Center in New York City

Because activated CD8+ T-cells depend on sustained glycolysis, excess extracellular lactate disrupts lactate efflux, leading to intracellular acidification and metabolic dysfunction that blunt T-cell activity within the GBM TME

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Baicalin-Geniposide combination modulates microglia polarization against chronic cerebral ischemia and concomitant kidney injury via the HIF-1alpha/EPO/NF-kappaB pathway