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Banhegyi G, Benedetti A, Margittai E, Marcolongo P, Fulceri R, Nemeth CE, Szarka A (2014) Subcellular compartmentation of ascorbate and its variation in disease states

PeerJ, 10 , Article e13683

(120) also identified that resveratrol supplementation combined with aerobic exercise likely exerts a stronger effect on increasing SIRT1 and PGC-1 expression in the soleus muscle and inguinal adipose tissue, as well as UCP-1 expression in inguinal adipose tissue, compared to either intervention alone

Experimental evidence points a multifactorial etiology, linking hyperglycemia with the activation of multiple cell phenomena such as polyol pathway, advanced glycation end-products formation, protein kinase C (PKC) and nuclear factor K signaling, among many others (Pacher, 2008