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The rs8187996 variant is located in the intron (non-coding) region, which has a minor effect on gene regulation ( 3.4 Mycophenolate mofetil MMF is a pro-drug for mycophenolic acid (MPA), which hinders inosine monophosphate (IMP), thereby suppressing the production of guanosine monophosphate (GMP) to initiate reduced proliferation of B and T cells, as well as diminished production of antibodies

Ruiz-Larrea MB, Leal AM, Liza M, Lacort M, de Groot H (1994) Antioxidant effects of estradiol and 2-hydroxyestradiol on iron-induced lipid peroxidation of rat liver microsomes

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