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Spider angioma, involving central arterioles surrounded by radiating capillaries, occurs in 33% of alcohol-associated cirrhosis cases and is also linked to hepatopulmonary syndrome, arising from increased blood flow to the surface capillaries

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Guanylate Cyclase-C Agonists (Linaclotide, Plecanatide): These agents reduce visceral hypersensitivity via cGMP signaling and provide pain relief in IBS-C, but diarrhea is the most common adverse effect limiting its use in certain patients [111,112,113]