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Statistical test used: one-way ANOVA (Tukeys multiple comparisons test)

CJC-1295 is also a GHRH-based peptide, but it is long-acting and stays active far longer

CJC-1295, by contrast, is a long-acting GHRH analogue with a half-life of 68 days, producing sustained low-level GH elevation

These treatments are often administered through injections, as this ensures that the peptides are absorbed directly into the bloodstream for maximum efficacy

As a triple incretin receptor agonist, it: Activates GLP-1 receptors , reducing appetite, slowing gastric emptying, and improving insulin secretion Activates GIP receptors , enhancing insulin response and potentially supporting fat metabolism Activates glucagon receptors , increasing energy expenditure and hepatic glucose output Whilst glucagon receptor activation increases hepatic glucose output, the net glycaemic effect of retatrutide is mitigated by the concurrent GLP-1 and GIP activity, resulting in overall improvements in glycaemic control in trial participants