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Understanding fundamental molecular and genetic mechanisms is necessary to develop new therapeutic approaches for NSCLC

Available from: [DOI] [PMC free article] [PubMed] 132.Bhowmik R, Chaubey B

However, in chronic infections, the balance of NFAT and AP-1 expression changes, with NFAT homodimers binding to the promoters of genes encoding inhibitory receptors, revealing the mechanism of AP-1s role in T-cell exhaustion (121)

However, bendamustine is generally not recommended for use in autoimmune disease patients due to its potential for high toxicity, severe immunosuppression, and the lack of safety and efficacy data in this population (172, 175)