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References (Sarkar R, et al

Nat Genet 46(4):357363

A methyltransferase-like 14/miR-99a-5p/tribble 2 positive feedback circuit promotes cancer stem cell persistence and radioresistance via histone deacetylase 2-mediated epigenetic modulation in esophageal squamous cell carcinoma

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Consistent with this hypothesis, treatments that induced only GCLC increased the GSH synthesis capacity by 50 to 100% [64,135], whereas treatments that induced both GCLC and GS expression increased the GSH synthesis capacity by 161200% [27,140]