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[24] [25] All tobacco products, including chewing, contain cancer-causing chemicals

Commercial sales became important in the late 19th century, as major tobacco companies arose in the South, becoming one of the largest employers in Winston-Salem, North Carolina, Durham, North Carolina, and Richmond, Virginia

"We believe Black Buffalo has the potential to capture substantial market share in the nearly $7.5 billion moist smokeless tobacco category, for which we believe no true alternative has existed to date for adult consumers." Robert Buhler, President and CEO of Open Pantry Food Marts, says, "The alternative nicotine category has seen explosive growth over the past few years in the convenience store channel

1 2 "Smokeless tobacco ( paan and gutkha ) consumption, prevalence, and contribution to oral cancer"