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doi: 10.1038/nature05859 77 YangWSSriRamaratnamRWelschMEShimadaKSkoutaRViswanathanVSet al

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4175-A SONIC HEDGEHOG EXPRESSION IN STEATOHEPATITIC HEPATOCELLULAR CARCINOMAS AND ITS CLINICOPATHOLOGIC SIGNIFICANCE Hironori Kusano 1,2 , Sachiko Ogasawara 2 , Minori Omuraya 2 , Masayuki Okudaira 3 , Shinji Mizuochi 2 , Yutaro Mihara 2 , Yoshinao Kinjyo 2 , Yuta Yano 2 , Masamichi Nakayama 2 , Reiichiro Kondo 2 , Yoshiki Naito 4 , Jun Akiba 4 , Osamu Nakashima 5 and Hirohisa Yano 2 , (1)National Hospital Organization Kokura Medical Center, (2)Kurume University School of Medicine, (3)National Hospital Organization Nagasaki Medical Center, (4)Kurume University Hospital, (5)St Mary's Hospital Background: The dysregulation of the Hedgehog signaling pathway has been reported to be implicated in the pathogenesis of non-alcoholic steatohepatitis, and the expression of the sonic hedgehog (SHh) protein, a pivotal molecule in the Hedgehog pathway, is found in ballooned hepatocytes