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10.1002/14651858.CD003495.pub3 304 WilliamsK.WrayJ

However, since less than 4% of a topically applied dose is systemically absorbed, the uptake of azelaic acid into maternal milk is not expected to cause a significant change from baseline azelaic acid concentrations in the milk

When you're conducting a study, you need to be absolutely certain that the compound you're working with at the end of the week is the same potent compound you started with

Common endpoints studied: Body weight change Nitrogen retention / protein synthesis Tissuespecific response Metabolic readouts (contextdependent) Dosing Protocol (Research context) Research Protocol (InVivo) Most Citable Structures A) Continuous infusion model (7 days): 0.9 mg/kg/day des(13) IGF1 7 days (osmotic minipump)

In mouse studies, measurable effects on organ function appeared within 10-14 days of treatment initiation