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doi: 10.1097/j.pain.0000000000000190 124 LinardCBussonEHollerVStrup-PerrotCLacave-LapalunJ-VLhommeBet al

Future research should prioritize longitudinal human studies that move beyond self-reports to include objective measurements of FKBP51 expression levels and cytokine profiles (e.g., IL-6, TNF-, CRP) to quantify homeostasis restoration. Furthermore, investigations into the potential reversibility of epigenetic patterns, such as DNA methylation of NR3C1 and FKBP5, through long-term cannabinoid therapy are necessary