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Action of brief pulses of glutamate on AMPA/kainate receptors in patches from different neurons of rat hippocampal slices

GLP-1 receptor agonists (semaglutide, tirzepatide) are peptide drugs cleared by proteolytic cleavage, not by hepatic CYP450 enzymes, so there is no enzymatic pathway linking the two

In line, expression of the catalytic alpha subunit of PDC (Pdha-1) was decreased in Gclc -deficient cells (Fig

A growing body of preclinical research continues to explore its mechanisms and applications, including emerging work on neuroprotective effects and potential roles in spinal cord injury recovery

injured tubules activate fibroblasts or undergo EMT to exacerbate RF, further reducing glomerular filtration rate ( 3.4.3 Targeting ferroptosis to ameliorate RF Ferroptosis is now recognized as a pivotal regulated necrotic pathway in AKI (196), and recurrent AKI drives maladaptive repairmarked by tubular atrophy, fibroblast activation, and excessive ECM depositionculminating in CKD and ESRD, where RF is nearly universal