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To validate the metformin-induced changes in TXNIP mRNA expression, we treated IEC6 and Caco-2 cells with biguanides

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In terms of angiogenesis, lactate can enter vascular endothelial cells via MCT1, leading to IB phosphorylation and subsequent degradation, thereby activating the NF-B pathway and upregulating IL-8 transcription, a key mediator of angiogenesis