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10.1523/jneurosci.23-08-03394.2003 136 ShimM

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Hence, it is tempting to speculate that tamoxifen efficacy in delaying the reoccurrence of breast cancer is due, in part, to its collateral sensitivity effect to selectively target P-gp overexpressing breast cancer cells

Stincone A, Prigione A, Cramer T, Wamelink MM, Campbell K, Cheung E, Olin-Sandoval V, Gruning NM, Kruger A, Tauqeer Alam M, Keller MA, Breitenbach M, Brindle KM, Rabinowitz JD, Ralser M

As organisms age, macrophages display reduced phagocytic activity, compromising innate immune defense mechanisms