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FGF21, by binding to its receptor FGFR1, activates the downstream PI3K/AKT signaling pathway, inhibits the activation of the inositol-requiring enzyme 1 (IRE1)/JNK pathway, and reduces the expression of apoptosis-related proteins such as C/EBP-homologous protein (CHOP) and claved-caspase3, thereby suppressing oxidative stress and apoptosis

Niacin deficiency often associated with malnutrition is observed in the homeless population, in individuals suffering from anorexia nervosa or obesity, and in consumers of diets high in maize and poor in animal protein (26-29)

doi: 10.1016/j.chembiol.2018.02.010 188 KannappanVAliMSmallBRajendranGElzhenniSTajHet al

(Landmark Ed.) 29 , 67 (2024)

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