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Free copper is extremely reactive through Fenton chemistry, and it stimulates the secretion of pro-inflammatory cytokines such as interleukin-1 (IL-1), IL-4, and tumor necrosis factor (TNF) in both the brain and the blood (Tokuda et al., 2009)

[DOI] [PubMed] [Google Scholar] 48.Liu W., Kato M., Akhand A.A., Hayakawa A., Suzuki H., Miyata T., Kurokawa K., Hotta Y., Ishikawa N., Nakashima I

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A recent blinded, randomized reintroduction RCT (2024) further confirmed this observation: among 117 patients, 80% showed significant symptom improvement after 6 weeks on a low-FODMAP diet (165)

therefore, mitochondrial dysfunction can potentially play a major role in the oxidative stress observed in SARS-CoV-2 viral infection