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[PubMed: 27317598] [CrossRef] 103

Moreover, cystine starvation induces mitochondrial fragmentation and ROS production, leading to necroptosis and ferroptosis in BLBC cells via the tumor necrosis factor alpha (TNF) and MEKK4-p38-Noxa pathways, while luminal-type breast cancer, without activation of these pathways, is cystine independent 48,49