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Levels can be increased by systemic administration and concentrate in the seminal plasma, where it can produce its physiologic and therapeutic roles

445 It is merely a temporary solution unless the patient permanently relocates to a lower altitude

For instance, it can be paired with platelet-rich plasma (PRP) therapy or other regenerative treatments that promote tissue healing and repair

The effect of hypoxemia and exercise on acute mountain sickness symptoms

Additionally, EPO modulates the activity of anti-eryptotic kinases (e.g., AMP-activated protein kinase, AMPK) to maintain erythrocyte membrane integrity (Fller et al., 2009b