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Del Re DP, Amgalan D, Linkermann A, Liu Q, Kitsis RN (2019) Fundamental mechanisms of regulated cell death and implications for heart disease

Diagnosis (vitamin B12 deficiency or pernicious anaemia) was treated as a binary response in analysis, as everybody in the pernicious anaemia group was also classed as having vitamin B12 deficiency, as pernicious anaemia is the most common cause of vitamin B12 deficiency

This makes S-Acetyl Glutathione a superior choice for supporting liver detoxification

Consequently, Keap1 fails to align with the E2 ubiquitin-conjugating enzyme and thus Nrf2 are no longer targeted for ubiquitination and degradation

& Nakase, H