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As understanding of PCOS evolves, IR is increasingly recognized as a key factor in the pathogenesis of the disorder, resulting in the widespread utilization of metformin, a medication that enhances insulin sensitivity, for the management of PCOS

Particularly, since at time of collection, this cohort appear to harbor overall similar levels of plasma-based amino acids, regardless of disease status or disease severity, indicating minimal differences in nutrition status

27 Under hypoxic conditions, intervened by hypoxia-inducible factor (HIF), there is a reduction in hepcidin expression, which promotes iron release