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10.1016/j.freeradbiomed.2022.02.028 117 ShenM.LiY.WangY.ShaoJ.ZhangF.YinG.et al (2021)

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Clinical trials have demonstrated that Gotu Kola improves symptoms of chronic venous insufficiency, reduces ankle swelling, and enhances microcirculation, making it useful for managing varicose veins and edema during long flights and in daily life [8][9]

Binding of GH to the GHR re-orientates and rotates the receptor subunits, which results in the transition from parallel transmembrane domains to one where the transmembrane domains separate at the point of entry into the cytoplasm