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Targeting HSPs in autoimmune diseases HSP90 inhibition and inflammatory control HSP90 inhibitors have shown notable immunomodulatory activity in preclinical autoimmune models, consistent with the role of HSP90 in stabilizing signaling proteins that amplify immune activation

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[PubMed: 22588194] Mehta B, Mascarenhas L, Zhou S, et al.: Inflammatory myofibroblastic tumors in childhood

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Global metabolomic analysis In contrast to the specific quantitative analysis provided by the targeted methods described above, global metabolomic analysis evaluates all detected constituents of a sample such as plasma, urine, tissues or cells, and may therefore detect responsive metabolites that are not predefined (hypothesis generating)