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Alleles associated with milder synthetic defects and coinheritance of thalassemia trait reduce clinical severity by reducing accumulation of excess globin

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NIES39_A07680 co-purified with PilQ, and its high-confidence AlphaFold-predicted structure aligns well with the large lower ring part of the isolated nozzle complexes, a feature absent in other secretins (Figs

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The GLS inhibitor CB-839 is currently entering phase I and II clinical trials as monotherapy and as polytherapy when combined with chemotherapy and/or immunotherapy