melanotic macule. Benign. Dark spot on labia (or lip). Analogous to lentigo simplex. Hyperpigmented basal keratinocytes & dermal melanophages. Slight ⬆️ in single basal melanocytes; NO nests. More info like this in A flat and oval-shaped melanotic

Comparative Antioxidant Profiles Property Glutathione (GSH) Ergothioneine (EGT) Redox activity Very high, dynamic Moderate, stable Chemical stability Low (constantly recycled) Very high Specific transporter No Yes (OCTN1/SLC22A4) Tissue accumulation Limited High (brain, liver, eyes) Mitochondrial protection Indirect (via GPx) Direct DNA protection Mitochondrial (primary) Nuclear and mitochondrial Intestinal degradation Partial Very low Human synthesis Yes (liver) No (dietary only) Mushrooms as the Only Known Source of Both Molecules While glutathione is also found in other foods asparagus, avocado, red meat ergothioneine is found almost exclusively in mushrooms

Plant strategies for enhancing access to sunlight

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The STAT3/HIF-1/fascin-1 axis plays an important role in the hypoxic microenvironment of RA synovium, facilitating endothelial-to-mesenchymal transition (EndoMT) of FLS and thereby promoting migration and invasion (133)

However, whether this metabolic flexibility contributes to the stemness potentials of MICs and the initiation of tumor metastasis in breast cancer remains unclear