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M1 macrophages, induced by Toll-like receptor ligands (e.g., LPS) or Th1 cytokines such as TNF-, IFN-, and colony-stimulating factor 2 (CSF2), are characterized by surface expression of TLR2, TLR4, CD80, and CD86 (84)

[28] It is a cofactor and acts on glutathione peroxidase

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It is therefore unsurprising that the LD 50 values for compounds 1 and 2 determined ex vivo have a similar discordance to that seen for PZQ when considering in vivo PK/PD: much like PZQ these compounds are schistosomicidal in vivo at sub LD 50 concentrations