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Patel said

In ALD, dysbiosis of the intestinal microbiota allows these lipid antigens to enter the liver, where they activate NKT cells [105,106,107]

129,130 Soluble A oligomers are the primary neurotoxic substances, 131,132,133 disruption of cell membrane integrity, 134 activation in inflammatory responses, 135,136 causes of calcium homeostasis imbalance 137 and mitochondrial dysfunction, 138,139,140 triggers in oxidative stress, 141 and damage factor of synapses

Mechanistically, it appears to influence nitric oxide pathways, growth factors, and vascular integrity

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