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JS was involved in the acquisition, analysis and interpretation of the in vivo vasculogenesis assay

Terephthalic acid (TPA) had been approved as a specific and sensitive probe for OH monitoring, which was a nonfluorescent molecule and could quantitatively react with OH to generate a fluorescent product hydroxylated terephthalic acid (HTPA) 26 , The H 2 O 2 concentration-dependent variation of TPA fluorescence intensity showed a linear relationship, and the calculated turnover frequency (TOF) of Gi-F was 2.2 10 2 s 1 , which was similar to that of conventional Fenton system (1.5 10 2 s 1 ) 27 , suggesting the appropriate catalytic activity for ferroptosis in cancer treatment (Supplementary Fig