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[203] reported a pH-responsive surface-functionalized mesoporous silica nanoparticle system for simultaneously delivering both growth factor bone morphogenetic protein-2 and the drug dexamethasone for osseointegration

*J Physiol Paris.* 95(1-6):295-301

The one and five year graft survival rate among non-perfused grafts was 97.1% and 95.2% while perfused grafts had 97.6% and 96.3% survival, respectively (p=0.09 and 0.06, respectively)

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Since tropomyosins organize actin filaments and stabilize stress fibers, which are the primary structures sensing mechanical cues, we propose that tropomyosins may be involved in the fibroblasts ability to sense and respond to increased tissue stiffness