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doi: 10.3389/fendo.2024.1431405

Don't forget the neck area

Specifically, EGFR activation triggers ERK-mediated phosphorylation and nuclear translocation of ACSS2, which binds to KAT2A, functioning as a lactyltransferase to promote H3K14/18la and facilitating Wnt/b-catenin, NF-kB, and PD-L1 expression