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Protonatable headgroups also provide buffering capacity, facilitating endosomal escape via the proton sponge effect

Smoking cigarettes involves a substantial amount of free radicals that may degrade exogenous and endogenous antioxidants, as well as dysregulate monocytes and vascular smooth muscle cells [70] Endothelial nitric oxide synthase (eNOS)- derived nitric oxide plays a crucial role in regulating platelet accumulation, vasodilation, and maintaining stability between smooth muscle cell growth and proliferation

While previous attempts to validate a bidirectional relationship between AMD and AD yielded conflicting results that did not support an inverse relationship (119, 120), a bidirectional two-sample Mendelian randomization analysis identified a causal effect where early-onset AMD due to germline genetic variation reduced the risk for AD (121)