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Among tumors with low mutational burdens, it has been proposed that epigenetic inhibitors can make these cancers more visible to the immune system by activating gene expression programs (4)

2017;36(2):429-437 Gorissen SHM

Transcription factors (Rorb, Dbx2, Lhx2, and Fezf2) drive mature gene expression, and 3D culture with FGF2 enhances their expression and astrocyte maturation (Lattke et al., 2021)