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In contrast, ferroptosis has emerged as a key driver of ARDS pathogenesis, contributing to epithelial and endothelial cell injury, oxidative stress, and immune dysfunction

We found we could use high doses or frequent doses of the drug with no off-target effects, Lucero said

Interestingly, in the context of the transgenic mice expressing the mutant human B-crystallin, heterozygous knockout of Nrf2 lessened reductive stress decreasing the expression of the enzymes involved in GSH biosynthesis and recycling, resulting in a decrease in GSH concentration and the GSH/GSSG ratio

They could be successfully used for our blocking-labeling assay (Supplementary Fig

Polynucleotides (PN): Polynucleotides (PN), also known as nucleic acids, are bioactive molecules that play a crucial role in cellular regeneration and tissue repair