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Together, these findings indicate that hepatocyte HuR deficiency compromises mitochondrial dynamics, thereby exacerbating both structural remodeling and functional mitochondrial deficits under basal conditions and following APAP-induced liver injury

Zito, E

Both sorafenib and sulfasalazine are FDA approved drugs that have been shown to induce ferroptosis and inhibit tumor growth, however, in addition to inhibiting SLC7A11, sorafenib acts as a multi-kinase inhibitor and sulfasalazine blocks prostaglandin production (136, 137)

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When this DNA repair pathway is not functional, cells are more sensitive to compounds that can damage the DNA such as DNA interstrand-crosslinking (ICL) agents and simple aldehydes 11