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For example, Ulixertinib, an established ERK2 inhibitor, has been modified to identify new structures with similar binding properties, showing promising pharmacodynamic and pharmacokinetic profiles in preclinical studies (Pathania et al., 2022[102])

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doi: 10.1016/j.eclinm.2021.101019

Swine IV (SIV) infection resulted in NLRP3 inflammasome activation, leading to IL-1 production in primary porcine alveolar macrophages (PAMs) [122]