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Deletion of COQ1 or COQ2 that are involved in early steps of CoQ 6 biosynthesis prevents the accumulation of early CoQ 6 intermediates, 3-hexaprenyl-4-hydroxybenzoic acid (HHB) and 3-hexaprenyl-4-aminobenzoic acid (HAB), while deletion of any one of the COQ3 - COQ9 genes that are required for later biosynthetic steps accumulate these early CoQ intermediates (Figure 3b)

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