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Fertil Steril (2000) 74:3138

doi:10.1093/jn/123.9.1554

doi: 10.3390/biomedicines10061337 22 BrooksJPEdwardsDJHarwichMDJr.RiveraMCFettweisJMSerranoMGet al

Thus, in addition to being apparently GH-independent, the testicular functions of IGF-I seem to be served by its local production (autocrine/paracrine action) without a major endocrine contribution by the circulating form of this factor