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Protein surface are colored as below: hydrophobic (white), positive charge (red), and negative charge (blue)

In addition to triggering the inflammatory response through lipotoxicity that causes hepatocyte injury or death, excess FFA in the liver can also exacerbate the inflammatory response through direct or indirect activation of TLR4

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The changes in 17-estradiol levels with aging are mirrored by the decline of collagen and elastin levels, which are shown in Fig

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