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(2017b)

doi: 10.1038/s41598-017-13739-9 9 RobertsABGuXBuffaJAHurdAGWangZZhuWet al

American Journal of Physiology-Endocrinology and Metabolism, 282(2), E474E482

Toxic levels of methotrexate can be rapidly and effectively decreased by intravenous administration of glucarpidase, which has been shown to induce a 99% or greater sustained reduction of serum methotrexate levels (Widemann 2014)