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SGK1 is activated by IGF1, PI3K and PDK1, and can induce phosphorylation of S6K and GSK3 in cardiomyocytes [54] and phosphorylation of FoxO3 in various cell types [55]

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Conclusion: We have achieved conditions and drug predictions of NASH with a spheroid model for its use in high-througput screening of clinical candidates in NASH