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Hence, the interactions caused and perpetuated by the overproduction of ROS within the proinflammatory milieu lead to a self-reinforcing vicious loop that significantly contributes to the pathogenesis of IBD

1 Background Metabolic reprogramming is a hallmark of malignant tumors ( Glutamine (Gln) metabolic reprogramming is a crucial aspect of tumor metabolic reprogramming and plays a significant role in the initiation and progression of tumors

Metabolomic pathway analysis demonstrated that these metabolites are involved in sulfurate amino acids metabolism, with respect to cysteine, and glutathione synthesis (Fig