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However, peptides with little clinical research were on the chopping block due to concerns of impurities and dangerous side effects linked to compounded treatments

Bock-Marquette and co-workers reported in Nature (2004) that Tb4 promotes cardiomyocyte survival post-myocardial-infarction in mice through PINCH/ILK/Akt signaling, and Smart and colleagues showed in 2007 that the same peptide mobilizes adult epicardial progenitor cells

Historically, trials have investigated the use of massive doses of steroids (e.g., gram doses of methylprednisolone)

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