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One of the biologically active components of Gotu Kola that is thought to contribute to the plant extract's well-documented skin regenerating, wound healing, and moisturizing properties

Mechanisms involve Nrf2-dependent upregulation of glutamate cysteine ligase in astrocytes, thereby balancing redox status and oxidative stress (Sharon et al., 2016)

[DOI] [PMC free article] [PubMed] [Google Scholar] 102.Ricart AD

While vitamin B1 is essential for general health, it is generally obtained through a balanced diet that includes foods like whole grains, lean meats, nuts, and seeds

Once CPBSN38L is accumulated in the tumor and internalized into the cancer cells, under US irradiation, the sonosensitizer Ce6 rapidly induces extensive production of intracellular reactive oxygen species (ROS), thereby initiating a cascade amplified ROS-responsive activation of PBSN38 to release the active SN38 for inducing cell apoptosis