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In addition, non-enzymatic reactions which are integral parts of the metabolic networks with essential roles in cellular metabolism, cannot be captured by the enzyme activity-based metabolomics approaches

2019;6:e00123

Thus, understanding these mechanisms is crucial for enhancing the delivery of PLGA nanoparticles across the BBB to minimize systemic toxicity Pharmacological drugs loaded PLGA nanoparticles for PD treatment Several studies demonstrated the effectiveness of PLGA nanosystem in encapsulating pharmacological treatments, thereby improving bioavailability, enhancing BBB penetration, and providing sustained drug release

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