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Published 2024-10-14 Inflammatory bowel disease (IBD) encompasses a spectrum of chronic inflammatory conditions affecting the gastrointestinal tract, notably ulcerative colitis (UC) and Crohn's disease (CD)

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This compartmentalization is critical, as rupture of the lysosomal membrane may result in the release of multiple hydrolytic enzymes into the cytoplasm, potentially leading to premature trypsinogen activation and the initiation of AP

One of the mechanisms in AD has been suggested to be protein instability, which results in protein aggregation [56]