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2) MCOLN1 (a lysosomal Ca 2+ exit channel that is a transcriptional target of TFEB) induces a high concentration of Ca 2+ microdomains near the lysosomal surface

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For instance, siBec1@PPN nanoparticles deliver siRNA against Beclin-1 to silence autophagy, reverse treatment resistance, and potentiate combined anticancer therapies [71]

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