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While many patients gradually improve, others continue to experience fatigue, pain, brain fog, dizziness, sleep disturbance, and neurologic symptoms that interfere with daily life

J Hepatol 2015

Although the detailed cell death signaling mechanisms are unknown, one recent report showed that cocaine toxicity was attenuated in p53-knockout (p53-KO) mice, suggesting the involvement of the p53-mediated apoptosis pathway [295]

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As we will discuss, this level of detailed mechanistic understanding is a necessary prerequisite for the rational development of effective prevention and treatment strategies for electrophile-based pathogenic states