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74 In one randomized, placebo-controlled, crossover trial that included 24 healthy participants aged 55 years and older who had no major sleep issues, 5 mg melatonin 30 minutes before bedtime in controlled experimental conditions increased sleep efficiency, mainly by increasing stage 2 NREM sleep and slightly shortening awakenings

(PubMed) Miettinen M, Turpeinen O, Karvonen MJ, Pekkarinen M, Paavilainen E, Elosuo R

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Importantly, this PCOS-like phenotype was ameliorated by either knocking out the speA gene in Bacteroides vulgatus or by administering the ADC inhibitor difluoromethylarginine (DFMA) to reduce agmatine production

In another research, a higher proportion of participants in the probiotic group had reduced TMAO after probiotic intervention (77)